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Fig. 3 | Genome Biology

Fig. 3

From: Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma

Fig. 3

Histone lactyation activated transcription of YTHDF2. a Distribution of H3K18 la sites relative to translation start site (TSS). b Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of H3K18 la peaks. c Bioinformatics analysis filtered YTHDF2 as a downstream target of H3K18la. d IGV tracks for YTHDF2 from ChIP-seq analysis. Sites a–g are distributed in the YTHDF2 genomic region, and sites c and d are the H3K18la peaks. e, f ChIP-qPCR assay of H3K18la status in the YTHDF2 genomic region in OCM1 (e) an CRMM1 (f) cells. g, h ChIP-qPCR assay of EP300 status in the YTHDF2 genomic region in OCM1 (g) and CRMM1 (h) cells. i, j Western blot were performed to test YTHDF2 expression in OCM1 (i) and CRMM1 (j) cells after treated with different concentrations of 2-DG or oxamate

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Genome Biology

ISSN: 1474-760X

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