Fig. 3

Modeling the dependence of sgRNA fold changes on sgRNA activity in base editing screens. a Schematic of the efficiency correction model for calculating the functional scores. b, c Experimental validation of the negatively correlated relationship between ln fold change and sgRNA editing activity (the relative editing efficiency for generating the variant), using a group of sgRNAs that could generate nonsense mutations in BRCA1 (b) or BRCA2 (c). Pearson’s correlation coefficients are shown