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Fig. 7 | Genome Biology

Fig. 7

From: Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression

Fig. 7

Bulk RNA-seq of aortae from HDR and PE2-edited mice. Scatter plots between a HDR (sgRNA) and b PE2 (pegRNA) mice. The position of differential Tspan2 normalized reads is indicated in red. There was no overlap in genes up- or downregulated between the HDR and PE2 scatter plots. Many of the upregulated transcripts, particularly in the pegRNA experiment, are due to large deviations in reads among single replicates. For a listing of the significantly regulated genes, please see Supplementary Table S2. n = 4 aortae for each genotype

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