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Fig. 5 | Genome Biology

Fig. 5

From: Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression

Fig. 5

Mouse Tspan2 and Tspan2os loci. a UCSC Genome Browser screenshot of the 5′ mouse Tspan2 locus and overlapping, divergently transcribed lncRNA, Tspan2os. The sequence of the CArG box shown here is the complement of that shown in Supplementary Fig. 1 due to direction of transcription in mouse versus human Tspan2. Note the CArG box falls within a high degree of mammalian conservation (red arrow). b qRT-PCR of Tspan2os RNA in aorta and bladder of indicated PE2-mediated genotypes. n = 4 aortae for each genotype

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