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Fig. 4 | Genome Biology

Fig. 4

From: Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression

Fig. 4

Spatial localization of Tspan2 mRNA in PE2-edited mouse tissues. Immunofluorescence (LMOD1) and RNA FISH (Tspan2) of blood vessels in wild type heart (a) and brain (b) versus Tspan2peg/peg CArG box mutant heart (c) and brain (d). The Tspan2 mRNA is indicated by the red dots in vascular smooth muscle cells (labeled green with LMOD1 antibody) of wild type blood vessels (a, b), but is nearly absent in CArG mutant vessels (c, d). Scale bars are 50 μm. Representative images from n = 2 mice

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Genome Biology

ISSN: 1474-760X

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