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Fig. 2 | Genome Biology

Fig. 2

From: Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression

Fig. 2

Spatial localization of Tspan2 mRNA in HDR-edited mouse tissues. Immunofluorescence (LMOD1) and RNA FISH (Tspan2) of wild type aorta (a) and heart (b) versus Tspan2sg/sg CArG box mutant (HDR) aorta (c) and heart (d). Arrows point to coronary vessels of the heart. Note decrease in Tspan2 mRNA (red dots) in vascular smooth muscle cells (labeled green with LMOD1 antibody) of aorta and coronary vessels in CArG box mutants (c, d). Scale bars are 50 μm. Representative images from n = 3 mice

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