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Fig. 7 | Genome Biology

Fig. 7

From: SRSF3 and SRSF7 modulate 3′UTR length through suppression or activation of proximal polyadenylation sites and regulation of CFIm levels

Fig. 7

CFIm inhibits pPAS usage through unproductive FIP1 recruitment in SRSF3-regulated transcripts. a Enrichment of UGUA motifs around sPASs, pPASs, and dPASs used in P19 cells. b UGUA motif enrichment around the pPAS and dPAS in CPSF6 targets and non-affected transcripts. c UGUA motif enrichment around the pPAS and dPAS in SRSF3 targets and non-affected transcripts. d Cumulative fraction of dual UGUA motifs upstream, downstream, and enclosing sPAS, pPAS and dPAS. E Binding motifs of FIP1 and CPSF5 derived from iCLIP in P19 cells. f Metaprofiles of normalized crosslink sites of CPSF5 and FIP1 around the pPAS and dPAS of SRSF3 targets compared to random PAS. Significant differences in CPSF5 and FIP1 binding are computed by a z-score approach. Positions with FDR ≤ 0.01 are indicated below. g Stacked bar charts showing the proportion of pPASs (upper panel) and dPASs (lower panel) that are associated with known CSE motifs. SRSF3-regulated 3′UTRs are compared to CPSF6-only targets and all 3′UTRs

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Genome Biology

ISSN: 1474-760X

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