Fig. 2

Identification of single cell eQTLs in fibroblast and iPSC subtypes. a The majority of single cell (sc) eGenes in fibroblasts are subtype specific. Further, the single cell eGenes that were detected in two or more fibroblast subtypes were significantly more likely to be detected as eQTLs in bulk fibroblast RNA-sequence data from the gene tissue expression (GTEx) database (p < 5 × 10⁻³²⁴, Cochran-Armitage test). b The total number of eGenes (on the diagonal) and percent that are also observed in other fibroblast subtypes further shows that most eGenes are unique to a given subtype. c Neighbouring fibroblast cell types were more likely to share common eGenes than distant cell types. d iPSC types demonstrate a similar level of cell specificity and none of the single cell eGenes-eSNP pairs that were observed in fibroblasts were observed in the iPSC subtypes that were generated from the same individuals. e Top eQTLs unique to a specific cell type exemplify the cell type specificity