Table 1 Summary of approaches that address sources of uncertainty in genome annotation. Highlighted in bold are key approaches related to probabilistic or ensemble-based methods
From: Addressing uncertainty in genome-scale metabolic model reconstruction and analysis
Approach | Sources of uncertainty | References |
|---|---|---|
Comparison of pipelines | Variability across databases | [19] |
Combining databases | Variability across databases | |
Template GEMs | Incomplete annotations in non-model organisms | |
Probabilistic annotation | Annotation errors | |
Probabilistic annotation + context Information | Annotation errors | |
Specific databases and high-throughput genomics | Annotation errors |