Fig. 2
From: Genetic variation and microRNA targeting of A-to-I RNA editing fine tune human tissue transcriptomes
Cis variation of RNA editing identified by edQTL and ASED analysis. a Quantile-quantile plot (qq-plot) testing association of RNA editing levels with cis genetic polymorphisms across 49 tissues. Black line indicates values for which the observed p value is equal to the expected p-value. b Scatter plot of the number of edQTL sites vs sample size across the 49 tissues. c Histograms of the number of edQTL sites (left) and ASED sites (right) across all tissues. Tissues are sorted by the number of edQTL sites. d Example of an edQTL site in the FAM129A gene. Box plots show the significant association of rs492126 with the editing level (Φ) at chr1:184761188 within the whole blood. Each dot represents data from a particular individual. The dashed red line represents a linear fit of the data. e Example of allele-specific RNA editing in the FAM129A gene. ASED analysis identifies RNA editing site chr1:184761188 with respect to heterozygous SNP rs492126. For each heterozygous individual (y-axis), blue and red points indicate editing levels for each allele (x-axis). Error bars represent likelihood-ratio test-based 95% confidence intervals of RNA editing levels inferred from allele-specific read counts. Average allelic Φ values are shown in parentheses