Skip to main content

Table 1 DNA methylation sites significantly associated with the traits at p < 3.3 × 10−7, in a MOMENT meta-analyses of AD, ALS and PD. Chr—chromosome number; Probe—probe identification number as provided by Illumina; bp—base pair position in the genome; Gene—closest genes the probe is annotated to, based on distance to transcription starting site, following the method described elsewhere [28]; Orien—DNA strand orientation, F = forward, R = Reverse [28]; bMETA—effects sizes (increase (positive sign) or decrease (negative sign) of methylation between cases and control per standard deviation unit) of meta-analysis results; pMETAp values of meta-analysis models; s.e.META—standard errors from meta-analysis; pMETA—p values from meta-analysis; Direction—direction of effect sizes, within each cohort (AUS, KCL, NL, SGPD, PEG, AIBL, respectively); I2—proportion of total variation in study estimates that is due to heterogeneity between the six cohorts in the meta-analysis [35]

From: Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders

Chr Probe bp Gene Orien bMETA s.e.META. pMETA Direction I2 Q pQ
6 cg03546163 35686586 FKBP5 R − 0.43 0.06 3.42 × 10−12 46.2 9.29 0.10
15 cg26272088 98900110 IGF1R F 1.39 0.20 5.74 × 10−12 ++++++ 0 2.11 0.83
2 cg24166814 55840142 F − 0.83 0.13 5.60 × 10−11 36.8 7.91 0.16
22 cg04431254 46288875 TTC38 F − 1.44 0.25 1 × 0−8 10.4 5.58 0.35
4 cg06690548 138241654 SLC7A11 R 0.52 0.09 1.36 × 10−8 ++++++ 60.2 12.58 0.03
8 cg14195992 47353350 SPIDR R − 0.85 0.15 1.48 × 10−8 40.4 8.38 0.14
4 cg17786255 107893233 RP11-286E11.1; SGMS2 R − 0.62 0.11 3.45 × 10−8 37.9 8.05 0.15
12 cg11881599 92420308 RP11-693 J15.4; CLLU1OS;CLLU1 R 0.85 0.15 3.57 × 10−8 ++++++ 0 2.25 0.81
9 cg13953978 129838509 USP20 F 0.99 0.18 5.28 × 10−8 ++++++ 0 0.93 0.97
1 cg17901584 54,888033 RP11-67 L3.4; DHCR24 F 0.48 0.09 1.39 × 10−7 +++++− 73.2 18.69 2.20 × 10−3
6 cg18120259 43926902 F 0.67 0.13 2.29 × 10−7 ++++++ 0 1.30 0.94
10 cg26033520 72244313 F − 0.58 0.11 2.74 × 10−7 81.1 26.40 7.47 × 10−5