Fig. 3
Accuracy of out-of-sample classification in each target cohort, measured by the area under the curve (AUC) statistics obtained from DNA methylation profile scores (MPS), using MOA (top-row) or MOMENT (bottom-row) results at p value < 1 × 10−4, from each discovery cohort (column). AD, Alzheimer’s disease (dark blue); ALS, amyotrophic lateral sclerosis (yellow); PD, Parkinson’s disease (gray); RA, rheumatoid arthritis (light blue); SCZ, schizophrenia (red). Bars indicate 95% confidence intervals of AUC values; m = number of probes used in the classifier; stars represent p values lower than Bonferroni threshold (i.e., p < 0.05/700 tests), from logistic regression