Fig. 2
Manhattan (a), quantile-quantile (b) and volcano plots (c) of the MOMENT meta-analysis, of ALS, PD, and AD cohorts (Ncases = 4328, Ncontrols = 2994). The solid black lines in a and c refer to the genome-wide significant p value threshold (p = 3.30 × 10−7) and the dashed line refers to the suggestive p value threshold (p = 1 × 10−5). The dashed lines in b mark the upper and lower confidence intervals at 95%, for the p values. λ is the genomic inflation factor (the median of χ2 test-statistics of all DNA methylation sites divided by its expected value under the null)