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Fig. 4 | Genome Biology

Fig. 4

From: ADAR1 is a new target of METTL3 and plays a pro-oncogenic role in glioblastoma by an editing-independent mechanism

Fig. 4

METTL3 silencing decreases ADAR1 protein level without affecting its mRNA and decreases cell proliferation after ADAR1 reduction. a, b Western blotting analysis and qRT-PCR of ADAR1 at day (d)1, d2, and d6 post doxycycline induction (shMETTL3–1) in U87MG cells. GAPDH was used as control. c Cell proliferation (MTS assay) of shMETTL3 U87MG cells compared to control cells at d1 to d7 post doxycycline (similar effect was observed in U118MG cells, see Additional file 2, Fig. S4). Values are represented as means ± SD, ***p ≤ 0.001

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