Table 1 Input parameters to the simATAC simulation step

Library size mean

μ₁, μ₂

The estimated means of two Gaussian modals of library size.

Library size standard deviation

σ₁, σ₂

The estimated standard deviations of two Gaussian modals of

library size.

Library size weight

w

The estimated weight parameter of the first Gaussian modal.

Non-zero cell proportion

P

The proportion of non-zero cells in real bin-by-cell matrix.

Polynomial coefficient

β

The estimated coefficients of polynomial model fitted to

the relation between bin non-zero cell proportions and bin means.