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Fig. 5 | Genome Biology

Fig. 5

From: My personal mutanome: a computational genomic medicine platform for searching network perturbing alleles linking genotype to phenotype

Fig. 5

An edgetic use case. “Network Viewer” can be used to identify potential driver edges in cancer (a). A subnetwork is shown for a specific protein, which contains all the known PPIs among the protein and its neighbors. oncoPPIs are in red and those are not oncoPPIs but have interface mutations are in blue. Clicking a PPI will load the information page of that PPI. The mutation distribution in different cancer types of a PPI page is shown in b. The “Edgetic Mutation Explorer” (c) has a PDB viewer, a sequence/mutation viewer for each protein in the PPI, and a table that lists the mutations. The interaction of PIK3R1-PIK3CA is used as an example. Both proteins are frequently mutated in multiple cancer types (b). Recurrent interface mutations (Cys420Arg of PIK3CA) are revealed (c) with significant clinical responses (dg)

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