Fig. 2

Information architecture and questions addressed by My Personal Mutanome. This figure illustrates the several main entities (such as protein and drug) and their relationships (indicated by edges) in My Personal Mutanome. Users can browse through all the information by following the architecture shown here. Three visualization tools were developed: “Network Viewer,” which shows the subnetwork of the significantly mutated edges of a certain protein; “Nodetic Mutation Explorer,” which bridges the mutations to the functional sites; and “Edgetic Mutation Explorer,” which displays the mutations on the protein-protein interaction interfaces. Both “Nodetic” and “Edgetic” come with a built-in protein 3D structure viewer. Drug responses and cancer patient survival were computed for the nodetic and edgetic mutations. Numbers indicate the questions addressed by the information and visualization provided by My Personal Mutanome