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Fig. 7 | Genome Biology

Fig. 7

From: Single-cell proteomic and transcriptomic analysis of macrophage heterogeneity using SCoPE2

Fig. 7

Exploring transcriptional and post-transcriptional regulation in single cells. a A total of 1490 cells analyzed by 10× Genomics were ordered based on the loadings of their first common principal component (CPC 1) and the abundance of NCL mRNA displayed. Similarly, 1490 cells analyzed by SCoPE2 were ordered based on CPC 1, and the abundance of NCL protein displayed. Cells having the same rank were paired to display the joint distribution of NCL. bd The same analysis as in a was performed for RHOC, TNFSF13B, and TP53. e Distributions of correlations between p53 protein (or the TP53 RNA) and the RNA levels of its target genes. The target genes are subset into those whose transcription is repressed by p53 (blue dotted boxplots) and those whose transcription is activated by the p53 (red boxplots). The correlations for p53 protein and TP53 mRNA are significantly (p < 0.001) different

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