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Table 2 GeneWalk identifies transcriptional regulators among highly connected genes with many significant functions in the JQ1 condition

From: GeneWalk identifies relevant gene functions for a biological context using network representation learning

Gene
(ranked by connectivity with other genes)
Most relevant biological process annotation
(GeneWalk with Pathway Commons knowledge base)
Gene has any significant transcription-related annotations (FDR = 0.125)?
FOXO4 Positive regulation of transcription by RNA polymerase II Yes
CTNNB1 Canonical Wnt signaling pathway involved in negative regulation of apoptotic process Yes
MYB Positive regulation of transcription by RNA polymerase II Yes
RUNX1 Hemopoiesis Yes
GABPB2 Positive regulation of transcription by RNA polymerase II Yes
CDKN1A DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest INDRA only
PPARG Response to lipid Yes
TFAP4 Positive regulation of transcription Yes
VCL Platelet aggregation No
TFDP2 Positive regulation of transcription by RNA polymerase II Yes
RUNX2 Hemopoiesis Yes
CDC5L Positive regulation of transcription by RNA polymerase II Yes
DICER1 Conversion of ds siRNA to ss siRNA involved in RNA interference No
RREB1 Positive regulation of transcription by RNA polymerase II Yes
TAL1 Positive regulation of transcription by RNA polymerase II Yes
MRE11 Double-strand break repair via nonhomologous end joining No
ELOVL6 Fatty acid elongation, saturated fatty acid INDRA only
EPAS1 Cellular response to hypoxia Yes
EDNRA Artery smooth muscle contraction INDRA only
SUPT16H DNA replication-independent nucleosome organization Yes
HIST2H2AC Chromatin organization No