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Fig. 3 | Genome Biology

Fig. 3

From: Integrative analyses of TEDDY Omics data reveal lipid metabolism abnormalities, increased intracellular ROS and heightened inflammation prior to autoimmunity for type 1 diabetes

Fig. 3

Heatmap of enriched pathways and metabolite groups before seroconversion. a KEGG metabolic pathways. b Metabolite classes. c KEGG signaling pathways. Colors indicate mean up- (red) or down- (blue) regulation of the pathway, while color intensity indicates significance level. For each time point, Gene Set Enrichment Analysis of time-specific NPLS-DA VIP loadings was performed, p values for each pathway were combined using Fisher’s method and adjusted for multiple testing. Pathway were selected for having a combined, Fisher adjusted p value < 0.05 in at least one combination of time points

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