Fig. 5
From: Mutational signatures: experimental design and analytical framework
Computational characterisation of experimentally generated mutational signatures. a Determination of quantitative difference (i.e. mutation number increase) between experimentally generated subclones and controls through a permutation test based on the distribution of baseline mutation burden in control subclones (orange). A p value ≤ 0.01 indicates significantly different mutation burden for experimentally generated subclones (red). b Schematic illustration of the distinction of mutational spectra between control and experimental subclones using the signal-to-noise ratio (SNR). Here, μControl and μExp denote the means of the mutational profiles of control subclones and experimental subclones, respectively; σControl and σExp denote the standard deviations of the mutation profiles of control and experimental subclones, respectively. In this example, subclones of experimental condition B can be more confidently separated from the control subclones