Fig. 3

Benchmark results of TF analysis tools on real scRNA-seq data. a Performance of DoRothEA, D-AUCell, metaVIPER, and SCENIC on all sub benchmark datasets in ROC space vs TF coverage. b Performance of DoRothEA, D-AUCell, and metaVIPER on all sub benchmark datasets in ROC vs TF coverage split up by combinations of DoRothEA’s confidence levels (A-E). a, b In both panels, the results for each tool are based on the same but for the respective panel different set of (shared) TFs. TF coverage reflects the number of distinct perturbed TFs in the benchmark data set that are also covered by the gene sets