Genetic ancestry and admixture in Latin America. a The global locations of the four LA populations analyzed here (green) are shown along with the locations of the African (blue), European (orange), and Native American (red) reference populations. The sources of the genomic data are indicated in the key. b ADMIXTURE plot showing the three-way continental ancestry components for individuals from the four LA populations—Colombia, Mexico, Peru, and Puerto Rico—compared to global reference populations. c The mean (±se) continental ancestry fractions for the four LA populations. d Chromosome painting showing the genomic locations of ancestry-specific haplotypes for an admixed LA genome.