A framework for transcriptome-wide association studies in breast cancer in diverse study populations

Table 2 Genes with GReX found in association with breast cancer-specific survival

Gene	Closest survival-associated SNP^a	Distance to closest survival-associated SNP^a	Hazard ratio, adjusting for adjacent GWAS-SNP (90% CI)^b	P value, adjusting for adjacent risk SNPs^b
AURKA	rs202100873	87.1 kb	0.84 (0.74, 0.94)	0.027
CAPN13	rs72068647	266.9 kb	1.18 (1.04, 1.33)	0.046
PIK3CA	rs66487567	271.9 kb	0.88 (0.78, 1.00)	0.096
SERPINB5	rs376302305	89.4 kb	0.84 (0.75, 0.94)	0.028

^aTop survival-associated SNP in cis-region of the given gene from GWAS for survival and distance of top cis-SNP from gene
^bFDR-adjusted hazard ratio, 90% confidence interval, and P value for association of GReX and breast cancer-specific survival, adjusting for adjacent survival-associated SNPs

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