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Table 1 Genes with GReX found in association with breast cancer-specific survival in AA women

From: A framework for transcriptome-wide association studies in breast cancer in diverse study populations

Region

Gene

Hazard ratio (90% CI)a

Z-statistica

P valuea

GReX R2 (h2)b

20q13.2

AURKA

0.83 (0.73, 0.95)

−2.52

1.5 × 10−3

0.021 (0.055)

2p23.1

CAPN13

1.22 (1.07, 1.41)

2.76

5.4 × 10−4

0.011 (0.047)

3q26.32

PIK3CA

0.85 (0.74, 0.97)

−2.34

3.2 × 10−3

0.020 (0.033)

18q21.33

SERPINB5

0.82 (0.72, 0.93)

−2.85

3.4 × 10−4

0.010 (0.026)

  1. aHazard ratio and FDR-adjusted 90% confidence intervals, Z-statistic, and P value of association of GReX with breast cancer-specific survival
  2. bCross-validation R2 of gene expression in AA models
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Genome Biology

ISSN: 1474-760X

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