Skip to main content
Fig. 4 | Genome Biology

Fig. 4

From: A framework for transcriptome-wide association studies in breast cancer in diverse study populations

Fig. 4

GWAS and TWAS results in AA women. a Manhattan plot of traditional GWAS on breast cancer survival. Genomic regions found to be significantly associated with survival in TWAS are represented in various colors. No SNVs reach Benjamini-Hochberg FDR-adjusted genome-wide significance. b Manhattan plot of TWAS on breast cancer survival. Genomic regions found to be significant at FDR-adjusted P < 0.10 are highlighted in red. The blue line represents a cutoff of FDR-adjusted α = 0.05 and the dotted black line represents a cutoff of FDR-adjusted α = 0.10. c Caterpillar plot of log-hazard rates with FDR-adjusted 90% confidence levels (X-axis) and genomic position (Y-axis). Results shown are significant at nominal P < 0.10. Genes highlighted in red represent genes with GReX significantly associated with survival at FDR-adjusted P < 0.10

Back to article page