Fig. 4
From: Systematic functional identification of cancer multi-drug resistance genes
Characterization of RDD1.a Schematic protein structure of RDD1. b Gene tree of RDD1 from birds to human. c CRISPR-Cas9 RDD1-targeting cells decreased their sensitivity to the drugs (as indicated) in HAP1 cells. d, e CRISPR-Cas9 RDD1-targeting HeLa cells decreased their sensitivity to vincristine (VCR) in xenograft tumor model. d Tumor growth and e overall survival are shown. All data represented as mean ± SEM (n = 4–6 mice per group). d One-way ANOVA followed by Tukey’s post hoc test or e log-rank test, **p < 0.01