Fig. 2

Putative dsRNAs are depleted in mRNA across organisms. Comparison of inverted duplicated sequences (potentially folding into dsRNA; red) to tandem duplicated sequences (control; blue) across a wide range of organisms. For each organism, we present the relative abundance of each of the two types of alignments. a In the mRNA molecules, the potential for dsRNA formation is strongly depleted in most organisms. b In contrast, pre-mRNA molecules exhibit, for most organisms, a number of potential dsRNA regions similar to that of the control