Skip to main content
Fig. 7 | Genome Biology

Fig. 7

From: A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells

Fig. 7

PLA therapy decreases AraC-resistant cells in AML cell lines. a PLA therapy, involves pre-treatment of leukemic cells with PFD and LY followed by AraC treatment, using half of the concentrations used for individual drugs in Figs. 4g and 5f. b Three different AML cell lines apart from THP1 were sequentially treated with indicated drugs, followed by assessment of cell viability and death. c, d Viability of MOLM13 cells treated with indicated drug combinations. Flow cytometric profiles of cells stained with annexin V and propidium iodide are shown (c). Cells were plated on methylcellulose media for colony formation, to test survival in the presence of drug combinations. Representative colony images and quantification of colonies are shown (d). *p ≤ 0.05. Data are represented as average ± SEM. See also Additional file 1: Figure S5

Back to article page