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Fig. 4 | Genome Biology

Fig. 4

From: Lisa: inferring transcriptional regulators through integrative modeling of public chromatin accessibility and ChIP-seq data

Fig. 4

Lisa can accurately identify key transcriptional regulators and co-regulators using Cistrome DB cistromes. Lisa analyses of up- and downregulated gene sets from a GR overexpression, b BCL6 knockdown, c MYC knockdown, and d SOX2 knockout experiments. The scatter plots show negative log10 Lisa p values of 1316 unique transcriptional regulators for up- and downregulated gene sets. Colors indicate log2 fold changes of the TF gene expression between treatment and control conditions in the gene expression experiments. Dots outlined with a circle denote transcriptional regulators that physically interact with the TF perturbed in the experiment, which is marked with a cross

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