Fig. 7

TF-binding patterns associated with cMHSs and sMHSs, respectively. a cMHSs and sMHSs associated with different TF families. Percentage of cMHSs and sMHSs associated with each TF family was calculated, and the percentage change for each TF family was calculated by minus the percentage of sMHSs from the percentage of cMHSs. Positive percentage change indicates that TF families are more enriched in cMHSs than in sMHSs. Negative percentage change indicates that TF families are more enriched in sMHSs than in cMHSs. b Positional bias of TF-binding motifs within cMHSs and sMHSs. The probabilities of motifs at each base pair within the ± 150-bp region from the center of sMHSs and cMHSs were calculated by CentriMo. The probabilities of TF-binding motifs at each base pair were plotted as heatmap and each line in the heatmap represents one motif. c Boxplot of numbers of TF families that interact with cMHSs- or sMHSs-enriched TF families