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Fig. 5 | Genome Biology

Fig. 5

From: Eleven grand challenges in single-cell data science

Fig. 5

Mutations (colored stars) accumulate in cells during somatic cell divisions and can be used to reconstruct the developmental lineages of individual cells within an organism (leaf nodes of the tree with mutational presence/absence profiles attached). However, insufficient or unbalanced WGA can lead to the dropout of one or both alleles at a genomic site. This can be mitigated by better amplification methods, but also by computational and statistical methods that can account for or impute the missing values

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