Fig. 6

Functional impact of differentially spliced events in C. elegans, D. melanogaster, and H. sapiens. a Proportion of each type of AS event in the three AS core sets for each studied species. b Percentage of exon skipping (top), intron retention (middle), and alternative splice donor and acceptor sites (ALT splice sites, bottom) events belonging to the different AS core sets located in UTRs or CDS gene regions. Among the latter category, the percentage of events that potentially affect protein levels or generate alternative protein isoforms is indicated (see “Methods” for details). Arrows indicate whether the levels of proteins are expected to increase or decrease in the stress or tissue-specific condition. Given the low number of events in some types of abiotic and biotic AS core sets, they are joined in a single group: stress core set. p values indicate significance as assessed by Wilcoxon rank-sum tests (P < 0.05 (*); P < 0.01 (**); P < 0.001 (***)). AS-NR, alternative spliced-non-regulated; n.s., not significant. Ath, A. thaliana; Cel, C. elegans; Dme, D. melanogaster; Hsa, H. sapiens