Fig. 5

Assessing divergence and candidate regulatory drivers of cell-type modules. a Network plots of the significant top 40 most divergent genes for each consensus (WB) cell-type module. The top 750 connections ranked by weighted topological overlap for the consensus network are shown as node edges. Nodes with larger number of connections appear more central in each network plot. Node size relates to kME divergence. Node color relates to mean expression fold-change between human and mouse (red—upregulated in human, blue—downregulated in human). Diverged genes are available in Table S3. b Bar plot showing the number of TFs with binding site enrichment (OR > 3; p < 0.05) in promoters of diverged genes for each consensus cell-type module. c Bar plot showing the top five TFs whose binding sites are enriched in promoters of diverged genes for each consensus cell-type module