Fig. 3

SPIN states are predictive of DNA replication timing. a Stratification of multi-fraction Repli-Seq based on the SPIN states. b Comparison with constitutive and developmentally regulated replication timing (RT) domains. The barplot shows what percentage of each SPIN state belongs to constitutive early, constitutive late, and developmentally-regulated RT domains, respectively. c Comparison with RT evolutionary patterns defined by Phylo-HMGP [30] between human and other non-human primate species. d A Genome Browser view of the prediction of Repli-seq signals based on the SPIN states together with histone marks. The tracks are (from top to bottom): histone modifications, SPIN states, multi-fraction Repli-seq, and the predicted Repli-seq signals. For multi-fraction Repli-seq, the signal in each genomic bin is normalized across all fractions and the color scale is shown at the bottom. The three highlighted regions in light blue are examples of early replicating domains. The two highlighted regions in light orange are examples of late replicating domains