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Fig. 6 | Genome Biology

Fig. 6

From: N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer’s disease

Fig. 6

Characterizing the role of m6A pathway in the molecular pathogenesis of Alzheimer’s disease using the fly model. a Eye phenotype following the knockdown of Drosophila METTL3, METTL14, and YTHDF on the TauR406W background. In each case, following knockdown, eye phenotype is aggravated compared to control. b Column graph showing climbing times of these flies compared to control. Knockdown of the components of m6A pathway resulted in increased climbing times compared to control. ****p value < 0.0001

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