Skip to main content
Fig. 1 | Genome Biology

Fig. 1

From: N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer’s disease

Fig. 1

Characterizing m6A in early to late brain development. a Number of cortical m6A sites in each gene region across 2-week, 4-week, 6-week, 26-week, and 52-week-old mice. b LC-MS/MS quantification of m6A levels in poly (A) + mRNA across neurodevelopment. c Motif identified using the 2-week cortex but is representative of all tissues and time points. d Cumulative frequency plot showing how methylation status correlates with mRNA expression levels. Genes that are hypermethylated at 6 weeks have a smaller 2wk/6wk log2 TPM ratio. e Gene ontology analysis of enriched biological processes of genes that are hypomethylated (blue) or hypermethylated (red) at 6 weeks compared to 2 weeks

Back to article page