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Fig. 7 | Genome Biology

Fig. 7

From: High-resolution analysis of cell-state transitions in yeast suggests widespread transcriptional tuning by alternative starts

Fig. 7

Genes expressing upstream alternative TSSs display a wide range of translational efficiencies. a Comparison of translation efficiencies (TE) across the cell-fate transitions T1 and T2 of genes that displayed a TSS switching event as described in Fig. 3c. TE values were obtained from Brar et al. [21]. We set the first time point of T1 (or T2) to 0 and other values being the TE differences between a later time point and the first time point. White colors indicate missing values. Asterisks after the gene labels indicate genes expressing LUTIs as defined by Cheng et al. [19]. b Box plots of TE values obtained from Brar et al. [21] for genes identified in T1 with TSS switching, separating into cases where the tandem TSSs were proximal to each other (< 80 bp, top panel) and cases where the tandem TSSs were distal to each other (≥ 80 bp, bottom panel). c Model for how transcription of the main TSSs and translational output are affected/regulated by alternative upstream TSSs. Top panel shows where alternative TSSs can be induced upon entering a cell-fate transition. Bottom panel shows how upstream alternative TSSs can influence expression from the main TSS during a cell-fate transition

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