Fig. 3From: SuperTAD: robust detection of hierarchical topologically associated domains with optimized structural informationThe enrichment of epigenetic characteristics at detected boundaries or within TADs for each method. a, b The fold change of structural proteins peak number (CTCF, RAD21, SMC3) between peaks (regions around boundaries) and background (regions located 400 kb away from the boundaries) for a GM12878 cells and b IMR90 cells. The methods in x-axis are ordered based on the average fold change across all the structural proteins for each cell line. c, d The cummulative bar diagram shows the fraction of TADs from three groups: enriched for H3K27me3 (FDR-corrected p value ≤0.1, the blue bar); enriched for H3K36me3 (FDR-corrected p value ≤0.1, the orange bar); no significant enrichment (FDR-corrected p value >0.1, the green bar). The methods in x-axis are sorted in the ascending order of the faction of the third group (no significant enrichment, FDR >0.1) for c GM12878 cells and d IMR90 cells. Note that we add both SuperTAD and SuperTAD(F) into the comparison, representing the results before and after the node filtering, respectivelyBack to article page