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Fig. 7 | Genome Biology

Fig. 7

From: Comprehensive integrative profiling of upper tract urothelial carcinomas

Fig. 7

a Supervised consensus clustering of TCGA bladder cancers using hypermethylated probes derived from UTUC EpiC-high vs EpiC-low. Note the presence of two subgroups: BLCA-C1 and BLCA-C2. While the earlier is hypermethylated and immune enriched, the latter is enriched for FGFR mutations and FGFR amplification and displayed FGFR3 overexpression. In addition, BLCA-C2 is an immune desert with no infiltration by T cells and fibroblasts. b Box plot showing the MeTIL score distribution according to EpiC signature. Note that BLCA-C1 harbored a higher score than the BLCA-C2 subgroup. c Box plot showing the neutrophils score distribution according to EpiC signature. Note that BLCA-C2 harbored a higher score than the BLCA-C1 subgroup. d Kaplan-Meier curves for the overall survival in the TCGA-BLCA cohort showing that the BLCA-C1 subgroup harbored a poor outcome as compared to the BLCA-C2 subgroup

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