Fig. 4

Analysis of upper tract urothelial carcinomas (UTUC) transcriptome. a Unsupervised mRNA clustering of 20 UTUC cases showing two clusters, with no clear association identified between them and clinical tumor features. b OncoPrint depicting UTUC subtypes according to the molecular consensus classification of muscle-invasive bladder cancers. Recurrent somatic mutations in those UTUC cases with available genetic data are also shown. c, d Immune and stromal gene expression scores in muscle-invasive (MI) and non-muscle-invasive (NMI) UTUC samples. e, f Immune and stromal gene expression scores in FGFR3-mutated and FGFR3 wild-type UTUC samples. DMBcluster: DNA methylation-based epi-cluster; MWBcluster: mutation weight-based cluster; RNAcluster: RNA expression-based cluster