Fig. 3From: Comprehensive integrative profiling of upper tract urothelial carcinomasAnalysis of mutational signatures and correlation with immunity. a Mutation signature analysis of upper tract urothelial carcinomas showing that signatures 1, 13, and 16 have the highest cumulative weight among the 30 signatures identified by Alexandrov. b Non-negative matrix factorization (NMF) showing three robust clusters based on the mutation weight matrix of different mutational signatures. MWBcluster C1 (nâ=â7), C2 (nâ=â8), and C3 (nâ=â15) were characterized by signature 16, signature 1, and signatures 13, respectively. c Violin plot showing no difference of DNA methylation tumor-infiltrating lymphocyte (MeTIL) score between the identified three clusters. d Violin plot showing no difference of DNA methylation tumor-infiltrating lymphocyte (MeTIL) score between signature 13 and other signatures. MWBcluter: mutation weight-based clusterBack to article page