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Fig. 3 | Genome Biology

Fig. 3

From: Comprehensive integrative profiling of upper tract urothelial carcinomas

Fig. 3

Analysis of mutational signatures and correlation with immunity. a Mutation signature analysis of upper tract urothelial carcinomas showing that signatures 1, 13, and 16 have the highest cumulative weight among the 30 signatures identified by Alexandrov. b Non-negative matrix factorization (NMF) showing three robust clusters based on the mutation weight matrix of different mutational signatures. MWBcluster C1 (n = 7), C2 (n = 8), and C3 (n = 15) were characterized by signature 16, signature 1, and signatures 13, respectively. c Violin plot showing no difference of DNA methylation tumor-infiltrating lymphocyte (MeTIL) score between the identified three clusters. d Violin plot showing no difference of DNA methylation tumor-infiltrating lymphocyte (MeTIL) score between signature 13 and other signatures. MWBcluter: mutation weight-based cluster

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