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Fig. 3 | Genome Biology

Fig. 3

From: Equivalent DNA methylation variation between monozygotic co-twins and unrelated individuals reveals universal epigenetic inter-individual dissimilarity

Fig. 3

Time-stability of evCpGs. a A subset of the dataset of Zhang et al that includes short-term longitudinal replicates obtained 3, 6, and 9 months apart. b A heatmap with unsupervised hierarchical clustering employing 296 out of the 333 evCpGs and equal number genetics-dependent negative control probes. Longitudinal replicates cluster together like negative control probes. c Epigenetic clock and drift of evCpGs. –log10(p values) for association are plotted against –log10(p values) for heteroscedasticity, with respect to age. The colors symbolize significance for association (red), heteroscedasticity (blue) or both (purple). d DNA methylation levels plotted against age for example evCpGs highlighted in c; males are represented in blue and females in pink, while mean bin methylation ± sd (window length = 10 years, offset = 2 years) are highlighted in red

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