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Fig. 4 | Genome Biology

Fig. 4

From: Integrated genomic and transcriptomic analysis reveals unique characteristics of hepatic metastases and pro-metastatic role of complement C1q in pancreatic ductal adenocarcinoma

Fig. 4

Reversed EMT and metabolism rewiring in HMs. a Compared to PT, HMs showed decreased activities of EMT and EMT related pathways (upper panel) as well as increased cell cycle activity (bottom panel). This phenomenon was experimentally validated by IFH assays of 35 paired PTs and HMs. b HMs showed significant upregulation of epithelial marker E-cadherin and downregulation of mesenchymal marker N-cadherin. c TGFβ1 and WNT5A that are ligands of TGFβ signaling and WNT signaling, respectively, were significantly upregulated in HMs. d Proliferative marker Ki67 and CCNA2 were upregulated in HMs compare to PTs. *0.01 < P < 0.05; **0.001 < P < 0.01; ***P < 0.001. e Oxidative phosphorylation, pentose phosphate pathway, and glycolysis were up-regulated in HMs. Top panel shows results of between-group comparisons. Bottom panel shows difference between HMs and PTs of individual cases. Green indicates up regulation while purple indicates down regulation in HM. f Gene expression heat-map of key components of pathways showed in e

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Genome Biology

ISSN: 1474-760X

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