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Fig. 5 | Genome Biology

Fig. 5

From: Roles of piRNAs in transposon and pseudogene regulation of germline mRNAs and lncRNAs

Fig. 5

piRNAs mediate transposon regulation of lncRNAs. a piRNA mediates post-transcriptional regulation of mRNAs. piRNA precursors are transcribed from piRNA clusters that contain transposon sequences and are processed into mature piRNAs. Mature piRNAs are then loaded onto Piwi proteins and guide the Piwi complex to target lncRNAs that contain complementary transposon sequences to degrade these lncRNAs [68]. b piRNA mediates transcriptional regulation of mRNAs. In a human breast cancer cell line (MCF7), the Growth Arrest Specific 5 (GAS5) lncRNA produces piRNAs that are associated with Piwi proteins [100]. This piRNA-Piwi complex then recruits WDR5 and the COMPASS epigenetic complex to the promoter of the TRAIL (transcription of tumor necrosis factor (TNF)-related apoptosis-inducing ligand) gene to modify its epigenetic status to promote its transcription

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