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Fig. 3 | Genome Biology

Fig. 3

From: Roles of piRNAs in transposon and pseudogene regulation of germline mRNAs and lncRNAs

Fig. 3

The piRNA-Piwi complex recruits canonical mRNA processing and localization machineries to regulate mRNAs. a In the Drosophila germline, the mRNA de-capping complex, which includes PCM, Me31B, DCP1, and DCP2 proteins, is recruited by the piRNA-Piwi complex to HeT-A mRNA to promote the decay of HeT-A mRNA [70]. b In Drosophila embryos, the piRNA-Piwi complex recruits the Smg protein and CCR4 complex to the 3′ UTR of nos mRNA to facilitate the degradation of nos mRNA [71]. c In the mouse testis, the piRNA-Piwi complex interacts with Caf1 bound to the 3′ UTRs of target mRNAs to execute mRNA degradation through the slicer activity of Piwi [72]

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