Fig. 5
Preexisting active chromatin features positively predict induced Ascl1 binding sites. a Mean mES/mEB chromatin feature tag enrichment at Ascl1 binding sites, divided into quartiles based on their association with BichromCHR sub-network scores. Sites belonging to the highest-scoring quartile are enriched for preexisting active histone modifications such as H3K4me2, H3K4me3, H3K27ac, and H3K9ac. The lowest-scoring quartile lack enrichment of any measured histone modifications. b The distribution of BichromCHR sub-network scores at genomic regions enriched for each of the mES/mEB chromatin features. c Median BichromSEQ and BichromCHR sub-network scores at Ascl1 sites that overlap mES/mEB ChromHMM states. Bubble size corresponds to relative proportion of Ascl1 binding sites. Median BichromSEQ sub-network scores are typically lower at states with high BichromCHR sub-network scores