Fig. 4

DAF analysis reveals RNA editing SNPs as the target of balancing selection. a, b DAF distributions of A/G (a) or non-A/G (b) editing SNPs. For non-A/G editing SNPs, only SNPs located in 3′UTR had enough number for the analysis. DAF was calculated using the genotype data from the 1000 Genomes Project. p values were calculated with the Kolmogorov-Smirnov test by comparing the DAF distribution of editing SNPs in a defined genic location with the distribution of SNPs in intergenic regions (Additional file 4: Table S3). The numbers of RNA editing SNPs in each genic location are shown in parentheses. Intergenic-A/G or Intergenic-non-A/G: all A/G or non-A/G SNPs located in the intergenic regions as control. c, d DAF distributions of A/G editing SNPs with A (d) or G (e) allele as the ancestral allele. In d, 5′UTR sites were not analyzed due to the limited number. e DAF distributions of non-A/G editing SNPs. Only SNPs that are with A allele as the ancestral allele and located in 3′UTR had enough number for this analysis. f DAF distributions of the SNPs located in the upstream and downstream of 3′UTR non-SNP editing sites. Intergenic, all SNPs located in intergenic regions