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Fig. 8 | Genome Biology

Fig. 8

From: Simultaneous epigenetic perturbation and genome imaging reveal distinct roles of H3K9me3 in chromatin architecture and transcription

Fig. 8

EpiGo-KRAB induced rearrangement of chromatin compartmentalization. a Hi-C heatmap shown the compartmentalization of the C19Q region in EpiGo-Control (dCas9) cells. H3K9me3 state, RNA level, PC1, and C19Q repeats (target sites) shown at the top of the Hi-C heatmap (Chr19: 28,000,000–59,000,000). Hi-C heatmap of a local region (chr19: 50,000,000–59,000,000) was used to show the local compartmentalization. Region 1-1 (a partial region 1), region 2, and region 3 were shown in cyan, pink, and yellow respectively. b Hi-C heatmap shown the compartmentalization of the C19Q region in EpiGo-KRAB (dCas9) cells. All the data processing and display are the same as a

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Genome Biology

ISSN: 1474-760X

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