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Fig. 10 | Genome Biology

Fig. 10

From: Simultaneous epigenetic perturbation and genome imaging reveal distinct roles of H3K9me3 in chromatin architecture and transcription

Fig. 10

A model for genome organization mediated by H3K9me3 in living cells. H3K9me3 spread continuously over hundreds of kilobases to megabases in silenced regions, but the spreading frequently stops at the transcriptional initiation sites in active regions. Loci or regions with H3K9me3 decorate on the surface of HP1α condensates, which mediates chromatin local compaction. H3K9me3 and local compaction does not result in widespread gene silencing in active regions, but induces large scale chromatin compartmentalization possibly by phase separation

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Genome Biology

ISSN: 1474-760X

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